Proline is such a percussionist in the world of amino acids. He's always in the shadow of the rest of the band, but without him all the music falls apart. Similarly, your body would fall apartif it ran out of proline.
That is why, together with a doctor of medicine, a master's degree in pharmacy and a clinical nutritionistI will give you the most important information about it.
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From this article you will learn:
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- What is proline, L-proline and D-proline. .
- What properties it has and what it does for you.
- What it does for you.
- In which products you will find proline. .
- What are the symptoms of deficiency and excess of this ingredient. .
- What arecontraindications and side effects with proline supplementation. .
See also:
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- The best collagen on the market .
- Best collagen for nails
- Best collagen for face
- Best collagen for wrinkles
- Best collagen for skin
- Best collagen for joints
- Best collagen for hair
- Best collagen for cellulite
- Best collagen for acne
- Best collagen for stretch marks
- Best collagen for scars
- Best collagen for bones
- Best collagen for drinkingandcollagen for drinking (effects)
What is proline?
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Proline is an endogenous amino acid protein - the body can produce it itself. It is mainly produced from glutamic acid (commonly found in animal organisms). Proline is one of the most important protein amino acidsand.
His unique structure allows the formation of proteins with specific structures - with turns and loops. These unusual structures are essential for the proteins to function properly and stabilise their tertiary structure (i.e. shape).
Proline is involved in processes such as protein synthesis, immune regulation and tissue development. Likelysine, it is also essential for the production ofcollagen, the richest protein in the human body, highlighting its importance for skin, joint and bone healthand.
What formula does proline have?
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Proline has the formula C5H9NO2. It is characterised by its unique structure and is a key component of collagen. In addition, its specific structure allows it to give unique shapes to protein structures, influencing their stability and function.
Proline is a key component of collagen.
Proline, L-proline and D-proline - what are the differences?
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Amino acids, such as proline, can exist in two spatial forms, super scientifically speaking, they arechiral. In the case of proline, a distinction is made between: L-proline and D-proline.
L-proline
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L-proline is one of the two forms of proline. It is biologically active and occurs naturally in the body. L-proline is a type of proline that is used in the production of proteins, including the key protein for health - collagen.
In short, L-proline is an actively biological variant of proline. It is the one that plays key structural and functional roles in the human body.
D-proline
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D-proline is the second form of proline, less common and biologically less active than L-proline. D-proline occurs naturally in some micro-organisms, such as bacteria, where it is involved in some specific biochemical processes.
In humans, the role of D-proline is significantly limited. Most human enzymes are unable to metabolise it. Nevertheless, human organisms have the ability to convert a certain amount of D-proline to L-proline by means of appropriate enzymes.
Human organisms have the ability to convert a certain amount of D-proline to L-proline by means of appropriate enzymes.
D-proline is not common, nor is it actively used in human metabolism.
As a rule, it is the amino acids with the 'L' configuration that are present in the body and show biological activity...
What about hydroxyproline?
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Hydroxyproline is a derivative of the amino acid proline, whose unique properties are due to an additional hydroxyl group.
The most important role of hydroxyproline is its role in collagen, which consists of three polypeptide chains that twist inwards and outwards.
Hydroxyproline helps stabilise this complex structure by forming water bridges, increasing the stability and strength of the entirecollagen protein.
In order to synthesise hydroxyproline, it is necessaryvitamin C. Any disruption in obtaining hydroxyproline may result in inhibition of further steps in collagen biosynthesis...
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What properties does proline have?
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Responsible for protein structure
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Proline is an unusual amino acid that plays a special role in protein structure. It is often found where the protein chain makes a turn, forming twists and loops. This property comes from the unique structure of proline and is crucial to the three-dimensional structure of proteins.
Proline also gives proteins rigidity, helping them to hold their shape. Not only does it affect the structure of proteins, but it also plays a vital role in cell signalling - the process by which cells communicate with each other.
Proline is a key contributor to the structure of proteins.
Responsible for collagen production
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Proline is one of the key amino acids in the body's collagen production process. Its key functions include:
- Peptide chain formation.Proline is essential for the formation of the basic structure of collagen - the triple helix. This amino acid is part of the peptide chain of collagen and influences the stability and structure of this helix.
- Hydroxylation.In the process of hydroxylation, enzymes modify certain proline molecules, converting them into hydroxyproline. This process is important for the stability of the collagen structure.
- Collagen resynthesis.Proline is also a key component in collagen resynthesis. Collagen resynthesis is a process that enables the body to repair and regenerate connective tissue.
Influences the wound healing process
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Proline is also involved in the wound healing process. It has several important functions that affect tissue reconstruction and regeneration. The most important of these include:
- Collagen formation.The wound healing process depends largely on collagen, and proline is one of the main components of this protein. Collagen forms the structure that supports the new tissue during healing. .
- Regulation of apoptosis;Proline may also play a role in regulating apoptosis (programmed cell death), which is essential for removing damaged cells and replacing them with new ones during the healing process.
- Angiogenesis and cell migration.The process by which new blood vessels are formed from existing ones is called angiogenesis. Proline can be associated with angiogenesis, which is crucial during the wound healing process. In addition, this amino acid may promote migration - the process by which cells move to where they are most needed, which is key in wound healing. .
- Fighting inflammation.The inflammatory process is a normal part of wound healing. Yet an excess of it can lead to continued damage. Proline may play a role in modulating the immune response and reducing inflammation. .
Helps joints
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Proline may help people with joint pain and reducethe likelihood of joint-related diseases.
- Builds collagen.Proline is a key component in buildingcollagen protein, which is essential in the formation of connective tissues that are important for joint health. This protects joints from wear and degenerative changes that can lead to ailments such as arthrosisand.
- Regenerates joint tissues.Proline is essential for regenerative processes, helping to repair damaged joint tissues and produce new, healthy cellsand. .
- Prevents inflammationand.
By supporting the immune system, proline can help reduce chronic inflammation, which is often the cause of joint problemsand..
Promotes heart health
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Proline is crucial for heart health. One of the main areas where it shows its positive effects is in the regulation of blood pressure.
It is essential for the production of collagen in the body, and it affects the elasticity and strength of blood vessel walls. Healthy blood vessels are more resistant to increased blood pressure, which minimises the risk of cardiovascular disease.
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Healthy vascular walls also mean a lower risk of aneurysms...
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What about cholesterol?
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Proline also has a positive effect on cholesterol control. It is a component of lipoproteins - the key molecules that transport fats in the body. When proline levels are normal, the process of transporting lipids (including cholesterol) is more efficient, helping to maintain healthy blood cholesterol levelsand.
Also, proline indirectly reducesoxidative stressby supporting glutathione production. Glutathione is one of the mainantioxidants that helps protect the body from free radical damageand.
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What is best for your skin?
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If you don't want to opt for a standardcollagen supplement(e.g. because of a vegan diet), you can beton supplements that will support the productionof the protein of youth. The best of these are supplements like proline+lysine+vitamin C. These are some of the most important ingredients for collagen production in the bodyand.
Proline supplementation reduces degradationof collagen fibers...
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Does proline help with depression?
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Some studies suggest links between amino acid metabolism (including proline) and certain psychiatric disorders, but these links are not yet fully understood and require further research.
Proline - uses
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- Dietary supplements.Proline is often added to dietary supplements as an essential amino acid for optimal body developmentand. .
- Cosmetics.Proline is used in cosmetology and skin care products. It is used in masks,face creams, lotions, etc.and. .
- Agriculture.Proline is used in agriculture, particularly to make plants more resistant to external factors such as droughtand. .
Where proline occurs - sources in food
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Proline in food can allow you to maintain adequate concentrations of this amino acid. A healthy diet is essential for the body's health. Where can you find proline in food?
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Type . | Productsand | ||
Meat and poultry . | Beef, lamb, chicken | meat and poultry | meat. |
Fish | Tuna, salmon, cod | Tuna. | |
Milk and milk products | Milk, cheeses, yoghurts | ||
Nuts and seeds | Nuts, pumpkin seeds, sesame | Nuts, pumpkin seeds, sesame | |
Vegetables and fruit | |||
| . | broccoli, asparagus, cabbage, Brussels sprouts, bananas |
It is worth remembering that a balanced diet usually provides sufficient proline and supplementation is unnecessary. The exception to this is other recommendations from a doctor or dietician.
Proline supplied by the diet protects the retina from degeneration caused by oxidative damage in the pigment epithelium...
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Proline deficiency
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Proline deficiency is not a very common phenomenon, so there is a lack of research on the subject. Nevertheless, there are some situations in which it can occur.
Proline deficiency is a common occurrence.
Cause of proline deficiencyand:
- Hereditary disorders of proline metabolism.These are rare genetic cases that render the body unable to metabolise proline properly. In extreme cases, this can lead to neurological problems, including developmental delays. .
- Nutrition.People who do not get enough protein in their diet can suffer from proline deficiency.
- Absorption-limiting diseases.Gastrointestinal diseases or problems with thelivercan interfere with the body's ability to absorb proline from food.
About 60% of the proline provided by the diet reaches the plasma - half of this is taken up by the liver and the rest goes to the other organs...
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Symptoms of proline deficiency
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Symptoms of proline deficiency are difficult to identify, as they are often combined with general protein deficiency or malabsorption associated with other health conditions.
Because proline is responsible for collagen production, a deficiency of this amino acid could theoretically affect skin, hair or joint health. But this is only a theory, as the specific symptoms of proline deficiency are not precisely identified.
Perhaps in the case of a hereditary disorder, proline deficiency could have an impact on collagen production.
In cases of inherited disorders of proline metabolism, the following symptoms may occurand:
- developmental delays, .
- neurological disorders, .
- convulsions, .
Note, most often these symptoms are rare and usually associated with serious metabolic disorders. Any deficiency, including proline, should not be diagnosed by yourself. If you are concerned about nutritional deficiencies, the best course of action is to contact your doctor or a nutritionist.
In the case of a proline deficiency, the body begins to break down collagen to obtainitfrom this protein...
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See also:
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- How to rebuild collagen .
Proline excess - symptoms and effects
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Under normal conditions, proline is converted in an appropriate manner so that it does not accumulate in excess. However, abnormalities in its metabolism can lead to too much of this amino acid in the body, resulting in a rare genetic condition known as hyperprolinaemiaand.
Hyperprolinaemia is a metabolic disorder. There are two types of it: hyperprolinaemia type I and type II.
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- Hyperprolinaemia type I- is usually asymptomatic, although some individuals may experience mild neurological problems. People with this condition have approx. 3-10 times more proline in the body than healthyand.
- Hyperprolinaemia type II- is more severe thantype I and can lead to mental development problems, seizures, uncontrolled movements (hyperkinesis) and behavioural problems. In this case, proline concentrations can be up to 10-15 times higher thanstandardand.
Each form of hyperprolinaemia results from a mutation in a specific gene pair. Both forms are inherited in an autosomal recessive manner, meaning that both copies of the gene must have mutations for the disease to develop.
What is the treatment for proline hyperplasia?
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The treatment of hyperprolinaemia, like other amino acid metabolic disorders, usually consists of a specialised diet and symptomatic treatment. It should be tailored individually to the patient's situation. If the excess proline is caused by a specific disease or condition, the most important goal is to treat this underlying problem.
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Important
Hyperprolinaemia can also occur in other conditions, such as malnutrition or liver disease. In particular, people strugglingwith elevated levels of lactic acid in the blood (lactic acidosis) may have hyperprolinaemia because lactic acid stops (inhibits) the breakdown of proline.
Increased plasma proline levels are seen in patients with type 2 diabetes, obesity or insulin resistance.
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Proline supplementsin tablets and capsules
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Most often, proline supplementation is unnecessary - the amino acid is naturally produced by the body. However, if your specialist has recommended that you take proline supplements, checkthe following products.
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Proline supplementation may be important during the reproductive period to improve fertility...
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Is there proline in the form of a medicine?
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No, there is no proline in drug form. All the preparations you can buy, even at a pharmacy, are dietary supplements. The price of these products is usually a few tens of zlotys.
The price of these products is usually a few tens of zlotys.
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Collagen preparations you can choose
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The main function of proline is to support the productionof collagen. Presumably that's what you want -collagen support for skin, hair, nailsand joints. So maybe it would be simpler to takejust collagen? Here's a list of the 10best collagen supplementson the market.
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{ product:1eiyihgASLfslgpBv80Tk1 }}
{ product:7oWtjJtmIVq1UJtl2nlbv5 }}
{ product:50HBCaQiAK7rywRIgM1nYm }}
{ product:fyjLpBuQHhzwzRvwxSI3V }}
{ product:3A6Dp6540L63Y3msHqwQCz }}
See also:
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- How to choose collagen
- How to choose collagen to drink
- How to choose collagen powder
- How to choose collagen in sachets
- How to choose liquid collagen
- How to choose collagen in tablets
- How to choose collagen in capsules
- How to choose fish collagen to drink
- How to choose fish collagen powder
- How to choose hydrolyzed collagen
- How to choose hyaluronic acid collagen
How to dose proline?
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The dosage of proline depends on various factors such as health, age, lifestyle and diet. Typically, safe and effective doses of this amino acid range from 500 mg to 1,000 mg per day.
Remember, however, that there are no clearly established dosages for proline supplementation, so it is always advisable to consult a doctor or nutritionist who will be able to tailor the dosage to your individual needs and health status.
Supplementation of the diet with amino acids while trying to have a baby can help alleviate reproductive disorders and thus improve fertility. Proline plays an important role in regulating gene expression, protein synthesis and angiogenesis during pregnancy. However, this should always be consulted with your healthcare provider...
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Proline contraindications
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Proline occurs naturally in the body, so most often its supplementation is safe and not associated with contraindications. Nevertheless, it is worth being careful and checking whether the following restrictions apply to you:
- Kidney disease.People with kidney disease should be particularly careful with proline supplementation, as excess amino acids can stress the kidneys.
- The following restrictions apply to proline supplementation.
- Diseasesliver.As with kidney disease, people with liver problems should consult their doctor before starting proline supplementation.
- Metabolic disorders.Some metabolic disorders can cause problems with metabolising proline. People with such problems should avoid supplementation. .
Proline can be 'fuel' for pathogenic microorganisms such as:Helicobacter pylori,Staphylococcus aureusandMycobacterium tuberculosis. The extra supply of proline can fuel the disease because the bacteria will have energy to act. This is important becauseHelicobacter pylori, orStaphylococcus aureusare quite common pathogens..
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See also:
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- Norwegian collagen
- What iscollagen
- Collagen type I
- Collagen type II
- Collagen type III
Proline and L-proline - side effects
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While proline occurs naturally in many foods and is safe for most people, its excessive supplementation can lead to some side effects. Possible side effects include:
- Kidney problems.An excess of proline can stress the kidneys, leading to problems with kidney function.
- Proline is not a good supplement.
- Gastrointestinal disorders.Some people may experience gastrointestinal problems such as nausea, vomiting or diarrhoea while taking proline supplements.
- Hypoglycaemia.Proline can lower blood sugar levels, leading to anxiety, sweating, tremors, dizziness and reduced appetite.
Expert opinions on proline: a doctor, a pharmacist and a clinical nutritionist
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Proline supports the immune system response by promoting the treatment of inflammatory bowel disease, increasing T-cell activity and reducing the secretion of pro-inflammatory cytokines..
Proline together with hydroxyproline is the main structural component of the collagen helix. Without it, collagen production would not be possible in the body. Proline is an endogenous amino acid (the body produces itit*elf), so supplementation is usually unnecessary...
Proline is synthesised in the body. It is a component of collagen - it helps build it, just as glycine is an essential building block of tissues such as ligaments, tendons, cartilage or muscles. Proline has particular properties in relation to wound healing and the appearance of the skin - it promotes resilience, elasticity and luminosity of the complexion...
Proline, together with other amino acids, regulates metabolic pathways to promote health, growth and development, as well as lactation. Furthermore, proline helps to maintain the normal function of the nervous system...
Because of their beneficial properties, many people choose to supplement glycine and proline separately, but it is worth noting that their effects are sort of indirect - collagen is responsible for everything, which supports just these amino acids. Therefore, the best solution if you want to support, for example, skin, hair, joints or nails, is to supplement with collagen rather than individual amino acids...
In in vitro studies, proline has an antioxidant effect and protects against the negative effects of free radicals...
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See also:
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- Which collagen is the strongest .
- Does collagen supplementation make sense .
- Collagen deficiency
- Collagen excess .
Summary
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- Proline is an endogenous protein amino acid. .
- There are two forms of proline: L-proline and D-proline, of which it is the former that is biologically active.
- Proline is an amino acid.
- Proline, among other things, supports protein structure, collagen production and the wound healing process. .
- Proline applications include, among others, dietary supplements and cosmetics. .
- Proline in food is found primarily in meat, fish and dairy products. .
- Proline deficiency is rare and does not have specific symptoms.
- Proline deficiency is rare.
- An excess of proline can becaused by metabolic disorders. .
- There is no specific dosage of proline. .
- Contraindications to the use of proline includekidney disease, liver disease and metabolic disorders.
- Side effects of L-proline and proline include, for example, kidney problems, gastrointestinal disorders and hypoglycaemia.
- Side effects of L-proline and proline include, for example, kidney problems, gastrointestinal disorders and hypoglycaemia.
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FAQ
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What is proline responsible for?
.Proline plays a key role in shaping the structure of proteins. Due to its unique structure, it is mainly responsible for the formation of loops and protein turns, which has a direct impact on the shape and function of the overall protein molecule.
Where is proline found?
.Proline is one of the 20 naturally occurring amino acids that are the building blocks of proteins. It is present in living organisms; it can be found in the proteins of plants, animals and humans. Proline helps form protein structures and is important for maintaining the integrityof collagen, a key protein for skin, bones, tendons and joints.
Proline is not localised to one specific site - it is widespread throughout the body in protein structures.
How much proline to takedaily?
.There is no universal recommended daily dose of proline. A suitable dose seems to be 500-1000 mg of proline per day. But it is always a good idea to consult your doctor or nutritionist before starting any supplementation to determine what dose will be safest and most effective for you.
What does it meanproline?
.Prolineis the English name for proline, an endogenous amino acid protein that is responsible for producingproteins and collagen in the body, as well as promoting wound healing.
What are the side effects of taking proline?
.Proline is an amino acid that is naturally produced by the body, so it is generally safe to consume. Nevertheless, taking proline, as with all dietary supplements, can potentially lead to side effects, especially when taken in large quantities.
Potential side effects may include:
- Gastrointestinal problems such as nausea, abdominal pain or diarrhoea.
- Increased burden on the gastrointestinal tract.
- Increased burden on the kidneys andliverdue to the need to process the extra amino acid.
- Possible imbalance of other amino acids in the body. .
Is proline an endogenous amino acid?
.Yes, proline is an endogenous amino acid. Endogenous amino acids are those that your body can produce on its own, so you don't necessarily need to provide them with food.
What formula does proline have?
.Proline has the chemical formula C5H9NO2. Its uniqueness is due to the fact that it is the only amino acid whose side chain forms a ring by bonding directly to the nitrogen atom of the amino group. It thus forms a five-membered cyclic system of four carbon atoms and one nitrogen atom.
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Sources
See all
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Doerfel, L. K., Wohlgemuth, I., Kothe, C., Peske, F., Urlaub, H., & Rodnina, M. V. (2013). EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues.Science,339(6115), 85-88.https://doi.org/10.1126/science.1229017
Guo, S., & DiPietro, L. A. (2010). Factors Affecting Wound Healing.Journal of Dental Research,89(3), 219-229.https://doi.org/10.1177/0022034509359125
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Karami, Z., & Akbari-adergani, B. (2019). Bioactive food derived peptides: A review on correlation between structure of bioactive peptides and their functional properties.Journal of Food Science and Technology,56(2), 535-547.https://doi.org/10.1007/s13197-018-3549-4
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Mathis, D., Beese, K., Rüegg, C., Plecko, B., & Hersberger, M. (2020). LC-MS / MS method for the differential diagnosis of treatable early onset inherited metabolic epilepsies.Journal of Inherited Metabolic Disease,43(5), 1102-1111.https://doi.org/10.1002/jimd.12244
Mayneris-Perxachs, J., Castells-Nobau, A., Arnoriaga-Rodríguez, M., Martin, M., de la Vega-Correa, L., Zapata, C., Burokas, A., Blasco, G., Coll, C., Escrichs, A., Biarnés, C., Moreno-Navarrete, J. M., Puig, J., Garre-Olmo, J., Ramos, R., Pedraza, S., Brugada, R., Vilanova, J. C., Serena, J., ... Fernández-Real, J. M. (2022). Microbiota alterations in proline metabolism impact depression.Cell Metabolism,34(5), 681-701.e10.https://doi.org/10.1016/j.cmet.2022.04.001
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Phang, J. M., Liu, W., & Zabirnyk, O. (2010). Proline Metabolism and Microenvironmental Stress.Annual Review of Nutrition,30(1), 441-463.https://doi.org/10.1146/annurev.nutr.012809.104638
Teymoori, F., Asghari, G., Farhadnejad, H., Nazarzadeh, M., Atifeh, M., Mirmiran, P., & Azizi, F. (2020). Various proline food sources and blood pressure: Substitution analysis.International Journal of Food Sciences and Nutrition,71(3), 332-340.https://doi.org/10.1080/09637486.2019.1650004
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